Agatha Christie: Death on the Nile is a seek-and-find mystery game in which players search for specific items/clues on a screen full of objects. Players – as detective Poirot – search through several rooms and interview suspects to find clues to solve a murder. In one room, the partially visible body of the victim is shown as well as a letter "J" written in blood above the victim. Wine is featured in the opening cinematic, while some of the items (selectable and background) include alcohol and tobacco products (e.g., cocktail glass, liquor bottle, cigarettes). Cutscenes depict images of a gun held to a woman's head as a flash appears when the weapon is fired. Another sequence depicts two characters in silhouette and still frames shooting themselves in an apparent suicide pact.